Meril Announces Prestigious LANCET Publication For Landmark RCT Of The MYVAL THV Series
This achievement reflects the success of the 'Make in India' initiative and validates India's ability to set new standards in cardiovascular care and transform heart valve treatment.
Meril Life Sciences has published its landmark trial study 'New-generation Myval Transcatheter Heart Valve series and modern (Sapien and Ewalt) THV series in patients with severe symptomatic aortic stenosis: a Randall non-inferiority study' in The Lancet. Indigenously developed Myval Transcatheter Heart Valve (THV) series.
This study compares the new generation Myval series and modern (Sapien and Evolt) THV series in patients with severe symptomatic localized aortic stenosis (AS). The results of the study show that the Myval THV series is no less than its world-class counterparts. The primary composite endpoint was a composite of death, stroke, major bleeding, acute kidney disease, major vascular complications, moderate or severe valve therapy, and the need for a pacemaker implant (according to the Third Valve Academic Research Consortium Consensus). Primary composite endpoint (24.7% Myvol THV series vs., 27.0% Modern THV series, non-statistical non-inferiority less than P 0.0001). This achievement reflects the success of the 'Make in India' initiative and validates India's ability to set new standards in cardiovascular care and transform heart valve treatment.
Aortic stenosis is a condition in which the aortic valve does not open completely, causing blood to not flow properly from the heart to the rest of the body. Due to this, the patient has many symptoms like chest pain, dizziness, and shortness of breath. Treatment of aortic stenosis depends on the severity of the condition. In severe aortic stenosis, the aortic valve is replaced with an artificial valve. This can be done through open heart surgery or minimally invasive procedures. A minimally invasive method of inserting a tube catheter through the femoral artery of the leg. This is called transcatheter aortic valve implantation (TAVI). The valve used in this is called the transcatheter heart valve.